2024

Ali M, Garcia P, Lunkes LP, Sciortino A, Thomas M, Heurtaux T, Grzyb K, Halder R, Coowar D, Skupin A, Buée L, Blum D, Buttini M, Glaab E. Cell Death Discov. Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations.  2024 Mar 7;10(1):119. doi: 10.1038/s41420-024-01885-9.

Basheer N, Buee L, Brion JP, Smolek T, Muhammadi MK, Hritz J, Hromadka T, Dewachter I, Wegmann S, Landrieu I, Novak P, Mudher A, Zilka N. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta Neuropathol Commun. 2024 Apr 4;12(1):52. doi: 10.1186/s40478-024-01748-5.

Benn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Aggregate-selective removal of pathological tau by clustering-activated degraders. Science. 2024 Aug 30;385(6712):1009-1016. doi: 10.1126/science.adp5186.

Blum D, Cailliau E, Béhal H, Vidal JS, Delaby C, Buée L, Allinquant B, Gabelle A, Bombois S, Lehmann S, Schraen-Maschke S, Hanon O; BALTAZAR study group. Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study. Alzheimers Dement. 2024 Oct;20(10):6948-6959. doi: 10.1002/alz.14169.

Bortolin V, Mansuroglu Z, Conquet L, Calcagno G, Lambert F, Marin-Obando JP, Segrt H, Savino M, Menidjel R, Souès S, Buée L, Niedergang F, Galas MC, Montagutelli X, Bonnefoy E. Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection. Glia. 2024 Oct 3. doi: 10.1002/glia.24619.

Comptdaer T, Tardivel M, Schirmer C, Buée L, Galas MC. Cell redistribution of G quadruplex-structured DNA is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression. Brain Pathol. 2024 Apr 22:e13262. doi: 10.1111/bpa.13262.

Delila L, Nebie O, Le NTN, Timmerman K, Lee DY, Wu YW, Chou ML, Buée L, Chou SY, Blum D, Devos D, Burnouf T. Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models. J Biomed Sci. 2024 Sep 5;31(1):87. doi: 10.1186/s12929-024-01072-z.

Dujardin K, Tard C, Diglé E, Herlin V, Mutez E, Davion JB, Wissocq A, Delforge V, Kuchcinski G, Huin V. Cognitive Impairment Is Part of the Phenotype of Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS). Mov Disord. 2024 May;39(5):892-897. doi: 10.1002/mds.29750.

Gomez-Murcia V, Launay A, Carvalho K, Burgard A, Meriaux C, Caillierez R, Eddarkaoui S, Kilinc D, Siedlecki-Wullich D, Besegher M, Bégard S, Thiroux B, Jung M, Nebie O, Wisztorski M, Déglon N, Montmasson C, Bemelmans AP, Hamdane M, Lebouvier T, Vieau D, Fournier I, Buee L, Lévi S, Lopes LV, Boutillier AL, Faivre E, Blum D. Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice. Brain. 2024 Aug 1;147(8):2691-2705. doi: 10.1093/brain/awae113.

Hamroun A, Decaestecker A, Larrue R, Fellah S, Blum D, Van der Hauwaert C, Scherpereel A, Cortot A, Lenain R, Maanaoui M, Pottier N, Cauffiez C, Glowacki F. Daily Caffeine Consumption May Increase the Risk of Acute Kidney Injury Related to Platinum-Salt Chemotherapy in Thoracic Cancer Patients: A Translational Study. Nutrients 2024, 16(6), 889; https://doi.org/10.3390/nu16060889

Hartnell, I.; Woodhouse, D.; Jasper, W.; Mason, L.; Marwaha, P.; Graffeuil, M.; Lau, L.; Norman, J.; Chatelet, D.; Buee, L.; Nicoll, J.; Blum, D.; Dorothee, G.; Boche, D. Glial Reactivity and T Cell Infiltration in Frontotemporal Lobar Degeneration with Tau Pathology. Brain 2024. 147:2, 590–606. https://doi.org/10.1093/brain/awad309.

Huin V, Blum D, Delforge V, Cailliau E, Djeziri S, Dujardin K, Genet A, Viard R, Attarian S, Bruneteau G, Cassereau J, Genestet S, Kaminsky AL, Soriani MH, Lefilliatre M, Couratier P, Pittion-Vouyovitch S, Esselin F, De La Cruz E, Guy N, Kolev I, Corcia P, Cintas P, Desnuelle C, Buée L, Danel-Brunaud V, Devos D, Rolland AS. Caffeine consumption outcomes on amyotrophic lateral sclerosis disease progression and cognition. Neurobiol Dis. 2024 Sep;199:106603. doi: 10.1016/j.nbd.2024.106603.

Le NTN, Han CL, Delila L, Nebie O, Chien HT, Wu YW, Buée L, Blum D, Burnouf T. Proteomics of human platelet lysates and insight from animal studies on platelet protein diffusion to hippocampus upon intranasal administration. APL Bioeng. 2024 May 6;8(2):026111. doi: 10.1063/5.0196553.

Leal CBQS, Zimmer CGM, Sinatti VVC, Soares ES, Poppe B, de Wiart AC, Chua XY, da Silva RV, Magdesian MH, Rafii MS, Buée L, Bottos RM. Effects of the therapeutic correction of U1 snRNP complex on Alzheimer's disease. Sci Rep. 2024 Dec 3;14(1):30085. doi: 10.1038/s41598-024-81687-2.

Lefebvre C, Vreulx AC, Dumortier C, Bégard S, Gelle C, Siedlecki-Wullich D, Colin M, Kilinc D, Halliez S. Integration of Microfluidic Devices with Microelectrode Arrays to Functionally Assay Amyloid-β-Induced Synaptotoxicity. ACS Biomater Sci Eng. 2024;10(3):1856-1868. doi: 10.1021/acsbiomaterials.3c00997.

Lehmann S, Schraen-Maschke S, Vidal JS, Delaby C, Buee L, Blanc F, Paquet C, Allinquant B, Bombois S, Gabelle A, Hanon O; BALTAZAR study group. Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment. J Neurol Neurosurg Psychiatry. 2024 Oct 16;95(11):1046-1053. doi: 10.1136/jnnp-2024-333467.

Lehmann S, Schraen-Maschke S, Buée L, Vidal JS, Delaby C, Hirtz C, Blanc F, Paquet C, Allinquant B, Bombois S, Gabelle A, Hanon O; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease. Mol Neurodegener. 2024 Oct 8;19(1):66. doi: 10.1186/s13024-024-00755-3.

Longhini AP, DuBose A, Lobo S, Vijayan V, Bai Y, Rivera EK, Sala-Jarque J, Nikitina A, Carrettiero DC, Unger MT, Sclafani OR, Fu V, Beckett ER, Vigers M, Buée L, Landrieu I, Shell S, Shea JE, Han S, Kosik KS. Precision proteoform design for 4R tau isoform selective templated aggregation. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320456121. doi: 10.1073/pnas.2320456121.

Mortelecque J, Zejneli O, Bégard S, Simões MC, ElHajjar L, Nguyen M, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Gomes CM, Buée L, Landrieu I, Danis C, Dupré E. A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein. J Biol Chem. 2024 Mar 12:107163. doi: 10.1016/j.jbc.2024.107163.

Paiva I, Seguin J, Grgurina I, Singh AK, Cosquer B, Plassard D, Tzeplaeff L, Le Gras S, Cotellessa L, Decraene C, Gambi J, Alcala-Vida R, Eswaramoorthy M, Buée L, Cassel JC, Giacobini P, Blum D, Merienne K, Kundu TK, Boutillier AL. Dysregulated expression of cholesterol biosynthetic genes in Alzheimer's disease alters epigenomic signatures of hippocampal neurons. Neurobiol Dis. 2024 Aug;198:106538. doi: 10.1016/j.nbd.2024.106538.

Schraen-Maschke S, Duhamel A, Vidal JS, Ramdane N, Vaudran L, Dussart C, Buée L, Sablonnière B, Delaby C, Allinquant B, Gabelle A, Bombois S, Lehmann S, Hanon O; BALTAZAR study group. Neurobiol Dis. The free plasma amyloid Aβ1-42/Aβ1-40 ratio predicts conversion to dementia for subjects with mild cognitive impairment with performance equivalent to that of the total plasma Aβ1-42/Aβ1-40 ratio. The BALTAZAR study. 2024 193:106459. doi: 10.1016/j.nbd.2024.106459.

Siew, J.; Chen, H.; Chiu, F.; Lee, C.; Chang, Y.; Chen, H.; Nguyen, T.; Liao, H.; Liu, M.; Hagar, H.; Sun, Y.; Lai, H.; Kuo, M.; Blum, D.; Buée, L.; Jin, L.; Chen, S.; Ko, T.; Huang, J.; Kuo, H.; Liu, F.; Chern, Y. Galectin-3 Aggravates Microglial Activation and Tau Transmission in Tauopathy. J Clin Invest 2024. https://doi.org/10.1172/JCI165523.

Vaillant-Beuchot L, Eysert F, Duval B, Kinoshita PF, Pardossi-Piquard R, Bauer C, Eddarkaoui S, Buée L, Checler F, Chami M. The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease. Cell Death Dis. 2024 May 28;15(5):367. doi: 10.1038/s41419-024-06742-2.

Welikovitch LA, Mate de Gerando A, Khasnavis A, Bhavsar H, Meltzer JC, Buée L, Chibnik LB, Bussiere T, Hyman BT. Tau, synapse loss and gliosis progress in an Alzheimer's mouse model after amyloid-β immunotherapy. Brain. 2024 Nov 6:awae345. doi: 10.1093/brain/awae345.

Zwang TJ, Sastre ED, Wolf N, Ruiz-Uribe N, Woost B, Hoglund Z, Fan Z, Bailey J, Nfor L, Buée L, Nilsson KPR, Hyman BT, Bennett RE. Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology. Cell Rep. 2024 Aug 27;43(8):114574. doi: 10.1016/j.celrep.2024.114574.