Publications

Toulotte F, Coevoet M, Liberelle M, Bailly F, Zagiel B, Gelin M, Allemand F, Fourquet P, Melnyk P, Guichou JF, Cotelle P,
Towards the design of ligands of the internal pocket TEADs C-terminal domain. Eur J Med Chem, 2025, 282:117026.

Mettu A, Glavatskikh M, Wang X, Lara Ordòñez A-J, Li F, Chau I, Ackloo S, Arrowsmith C, Bolotokova A, Ghiabi P, Gibson E, Halabelian L, Houliston S, J.Harding R, Hutchinson A, Loppnau P, Perveen S, Seitova A, Zeng H, Schapira M, Taymans J-M, Kireev D,
Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge. Chem Sci, 2025, Online ahead of print.

Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Portugal B, Lee PC, May P, Bobbili D, Radivojkov Blagojevic M, Lichtner P, Singleton AB, Hernandez D, Edsall C, Mellick GD, Zimprich AA, Pirker W, Rogaeva EA, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli AL, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van De Warrenburg BPC, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan MM, Krainc D, Burbulla LF, Farrer M, Kruger R, Gasser T, Sharma M, Elbaz A; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD) Consortium.
Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study. Neurology, 2024, 103(3):e209620

Landoulsi Z, Sreelatha AAK, Schulte C, Bobbili DR, Montanucci L, Leu C, Niestroj LM, Hassanin E, Domenighetti C, Pavelka L, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Portugal B, Edsall C, Kru Ger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Burbulla LF, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BP, Bloem BR, Singleton AB, Toft M, Pihlstrom L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Krainc D, Farrer MJ, Lal D, Elbaz A, Gasser T, Krüger R, Sharma M, May P,
Genome-wide association study of copy number variations in Parkinson's disease. MedRxiv, 2024

Hernandez CC, Gimenez LE, Strassmaier T, Rogers M, Taymans JM,
Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies. Front Mol Neurosci, 2024, 17:1414816.

Taymans JM, Yilmazer-Hanke D,
Editorial: Editors' showcase: molecular signalling and pathways. Front Mol Neurosci, 2024, 17:1479278.

Iannotta L, Fasiczka R, Favetta G, Zhao Y, Giusto E, Dall'Ara E, Wei J, Ho FY, Ciriani C, Cogo S, Tessari I, Iaccarino C, Liberelle M, Bubacco L, Taymans JM, Manzoni C, Kortholt A, Civiero L, Hilfiker S, Lu ML, Greggio E,
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner. Cell Death Dis, 2024, 15(10):752.

Dujardin K, Tard C, Diglé E, Herlin V, Mutez E, Davion JB, Wissocq A, Delforge V, Kuchcinski G, Huin V,
Cognitive Impairment Is Part of the Phenotype of Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS). Mov Disord, 2024, 39(5):892-897.

Entrenaa JM, Artacho-Cordóna A, Ravez S, Liberelle M, Melnyk P, Toledano M, Almendros P, Cobosa EJ, Marco-Contelle J,
The Proof of Concept of 2-{3-[N-(1-Benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the Therapy of Neuropathic Pain. Bioorganic Chemistry, 2024, 150:107537.

Morez M, Lara Ordóñez AJ, Melnyk P, Liberelle A, Lebegue N, Taymans JM,
Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date. Expert Opinion on Therapeutic Patents, 2024, 34(9):773-788.

Mazhari Dorooee D, Ravez S, Vertommen D, Renault N, Papadopoulos N, Marteau R, Charnelle E, Porte K, Gobert A, Hennuyer N, Herinckx G, Staels B, Melnyk P, Constantinescu SN, Frédérick R, El Bakali J,
LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode ChemRxiv, 2024

Laversin A, Dufossez R, Bolteau R, Duroux R, Ravez S, Hernandez-Tapia S, Fossart M, Coevoet M, Liberelle M, Yous S, Lebègue N, Melnyk P*,
Novel Quinazoline Derivatives as Highly Effective A2A Adenosine Receptor Antagonists Molecules, 2024, 29(16):3847.

Stoup N, Liberelle M, Lebègue N, Van Seuningen I,
Emerging paradigms and recent progress in targeting ErbB in cancers. Trends Pharmacol Sci, 45(6):552-576

Naaldijk N, Fernández B, Fasiczka R, Fdez E, Leghay C, Croitoru I, Kwok JB, Boulesnane Y, Vizeneux A, Mutez E, Calvez C, Destée A, Taymans J-M, Vinagre Aragon A, Bergareche Yarza A, Padmanabhan S, Delgado M, Alcalay RN, Chatterton Z, Dzamko N, Halliday G, Ruiz-Martínez J, Chartier-Harlin M-C, Hilfiker S.
A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells. NPJ Parkinson’s disease, 2024, 10(1): 12.

Boutin JA, Liberelle M, Yous S, Ferry G, Nepveu F.
Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems. J Pineal Res, 2023, accepted.

El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference, Angew Chem Int Ed Engl, 2023, 62(17), e202300221.

Dussart-Gautheret J, Rivollier J, Simon C, De Simone A, Berthet J, Delbaere S, Maruchenko R, Troufflard C, Lesage D, Gimbert Y, Lemière G, Marlière P, Fensterbank L.
Synthesis and Enzymatic Conversion of Amino Acids Equipped with the Silanetriol Functionality: A Prelude to Silicon Biodiversification, ChemistryEurope, 2023, e202300058 (1 of 5).

Ekmen A, Doulazmi M, Meneret A, Jegatheesan P, Herve A, Damier P, Gras D, Roubertie A, Piard J, Mutez E, Tarrano C, Welniarz Q, Vidailhet M, Worbe Y, Gallea C, Roze E.
Non-Motor Symptoms and Quality of Life in Patients with PRRT2-Related Paroxysmal Kinesigenic Dyskinesia. Mov Dis Clin Pract, 2023, accepted.

Fillatre P, Mailles A, Stahl JP, Tattevin P.
Scientific Committee and Investigators Group. Characteristics, management, and outcomes of patients with infectious encephalitis requiring intensive care: A prospective multicentre observational study. J Crit Care, 2023, 77, 154300.

Fnaiche A, Mélin L, Suárez NG, Paquin A, Vu V, Li F, Allali-Hassani A, Bolotokova A, Allemand F, Gelin M, Cotelle P, Woo S, LaPlante SR, Barsyte-Lovejoy D, Santhakumar V, Vedadi M, Guichou JF, Annabi B, Gagnon A.
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg Med Chem Lett., 2023, 95, 129488.

Filippini F, Nola S, Zahraoui A, Roger K, Esmaili M, Sun J, Wojnacki J, Vlieghe A, Bun P, Blanchon S, Rain JC, Taymans J-M, Chartier-Harlin M-C, Guerrera C, Galli T.
Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs. Cell Rep, 2023, 42(3), 112221.

Graça V, Berthet J, Delbaere S, Coelho PJ.
Photochromism of 2H-naphtho[1,2-b]pyran-4-carboxylates, Dyes Pigments, 2023, 212, 111130.

Iannotta L, Emanuele M, Favetta G, Tombesi G, Vandewynckel L, Lara Ordóñez AJ, Saliou J-M, Drouyer M, Sibran W, Civiero L, Nichols RJ, Athanasopoulos P, Kortholt A, Chartier-Harlin M-C, Greggio E, Taymans J-M.
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation. Front Mol Neurosci, 2023,16, 1269387.

McColgan P, Thobhani A, Boak L, Schobel SA, Nicotra A, Palermo G,Generation HD1 Investigators.
Tominersen in Adults with Manifest Huntington's Disease. N Engl J Med, 2023, 389, 203-22.

Mutez E, Swiderski M, Devos D, Moreau C, Baille G, Degardin A, Ryckewaert G, Carriere N, Kreisler A, Simonin C, Rouaix N, Tir M, Krystkowiak P, Ramdane N, Génin M, Sablonnière B, Defebvre L, Huin V.
Indication for molecular testing by multiplex ligation-dependent probe amplification in parkinsonism. Eur J Neurol, 2023, 30(6), 1667-1675.

Petitgas P, Tattevin P, Mailles A, Fillâtre P, Stahl JP, ENCEIF scientific committee investigators group.
Infectious encephalitis in elderly patients: a prospective multicentre observational study in France 2016-2019, Infection, 2023, 51(4), 859-867.

Petrova L, Gergov N, Stoup M, Zapryanova S, Van Damme EJM, Lebègue N, Liberelle M, Zasheva D, Bogoeva V.
Jacalin-Curcumin Complex Sensitizes the Breast Cancer MDA-MB-231 Cell Line. Int J Mol Sci., 2023, 24(24), 17399.

Picard L, Mailles A, Fillâtre P, Tattevin P, Stahl JP, ENCEIF scientific committee, investigators group.
Encephalitis in travellers: a prospective multicentre study. J Travel Med, 2023, 30.

Rapetti-Mauss R, Nigri J, Bérenguier C, Finetti P, Simha Tubiana S, Labrum B, Allégrini B, Pellissier B, Bousquet C, Dusetti N, Bertucci F, Guizouarn H, Melnyk P, Borgese F, Tomasini R, Soriani O.
Sig-1R/KCNN2 channel complex sets a signalling hub bolstering CAF-triggered metastatic process in pancreatic cancer, Gut, 2023, 72(4):722-735.

Rolland AS, Touzet G, Carriere N, Mutez E, Kreisler A, Simonin C, Kuchcinski G, Chalhoub N, Pruvo J-P, Defebvre L, Reyns N, Devos D, Moreau C.
The Use of Image Guided Programming to Improve Deep Brain Stimulation Workflows with Directional Leads in Parkinson's Disease. J Parkinsons Dis, 2023, 10, 12.

Sugier PE, Lucotte EA, Domenighetti C, Law MH, Iles MM, Brown K, Amos C, McKay JD, Hung RJ, Karimi M, Bacq-Daian D, Boland-Augé A, Olaso R, Deleuze JF, Lesueur F, Ostroumova E, Kesminiene A, de Vathaire F, Guénel P; EPITHYR consortium; Sreelatha AAK, Schulte C, Grover S, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin M-C, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BPC, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen N, Ran C, Belin AC, Puschmann A, Rödström EY, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Kruger R, Gasser T, Sharma M, Comprehensive
Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers. Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease, Mov Disord, 2023 Feb 14.

Tautou M, Descamps F, Larchanché PE, Buée L, El Bakali J, Melnyk P, Sergeant N.
A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology. Int J Mol Sci, 2023, 24(6), 5285.

Taymans J-M, Fell M, Greenamyre T, Hirst WD, Mamais A, Padmanabhan S, Peter I, Rideout H, Thaler A.
Perspective on the current state of the LRRK2 field. NPJ Parkinsons Dis, 2023, 9(1), 104.

Taymans J-M, Mutez E, Sibran W, Vandewynckel L, Deldycke C, Bleuse S, Marchand A, Sarchione A, Kreisler A, Simonin C, Koprich J, Baille G, Defebvre, Dujardin K, Destée A, Chartier-Harlin M-C.
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers, NPJ Parkinson’s disease, 2023, 9(1), 21.

Aidibi Y, Beaujean P, Quertinmont J, Stiennon J, Hodée M, Leriche P, Berthet J, Delbaere S, Champagne B, Sanguinet L.
A molecular loaded dice: When the π conjugation breaks the statistical addressability of an octastate multimodal molecular switch, Dyes Pigments, 2022, 202, 110270.

Bdair H, Singleton TA, Ross K, Jolly D, Kang MS, Aliaga A, Tuznik M, Kaur T, Yous S, Soucy JP, Massarweh G, Scott PJH, Koeppe R, Spadoni G, Bedini A, Rudko DA, Gobbi G, Benkelfat C, Rosa-Neto P, Brooks AF, Kostikov A.
Radiosynthesis and In Vivo Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors, ACS Chem Neurosci, 2022, 13(9), 1382-1394.

Blaise AS, Cuvelier E, Carrière N, Devos D, Moreau F, Defebvre L, Mutez E.
Use of levodopa-carbidopa intestinal gel to treat patients with multiple system atrophy, Parkinsonism Relat Disord, 2022, 100, 41-44.

Bolteau R, Duroux R, Laversin A, Vreulz B, Shiriaeva A, Stauch B, Han G-W, Cherezov V, Renault N, Barczyk A, Ravez S, Coevoet M, Melnyk P, Liberelle M, Yous S.
High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists, Eur J Med Chem, 2022, 241, 114620.

Cogo S, Y Ho F, Tosoni E, E Tomkins J, Tessari I, Lannotta L, J Montine T, Manzoni C, A Lewis P, Bubacco L, Chartier Harlin M-C, Taymans J-M, Kortholt A, Nichols RJ, Cendron L, Civiero L, Greggio E.
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation, Brain Res, 2022, 1778, 147781.

Coku I, Mutez E, Eddarkaoui S, Carrier S, Marchand A, Deldycke C, Goveas L, Baille G, Tir M, Magnez R, Thuru X, Vermeersch G, Vandenberghe W, Buée L, Defebvre L, Sablonnière B, Chartier-Harlin M-C, Taymans J-M, Huin V.
Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease, Mov Disord, 2022, 37(8), 1761.

Domenighetti C, Douillard V, Sugier P-E, Ashwin Ashok Kumar Sreelatha, Schulte C, Grover S, May P, R. Bobbili D, Radivojkov-Blagojevic M, Lichtner P, B. Singleton A, G. Hernandez D, Edsall C, Gourraud P-A, Mellick D, Zimprich A, Pirker W, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol J-C, Chartier-Harlin M-C, Mutez E, Brockmann K, B. Deutschländer A, M. Hadjigeorgiou G, Dardiotis E, Stefanis L, Maria Simitsi A, Maria Valente E, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Ju Chung S, Joong Kim Y, Kolber P, PC van de Warrenburg B, R. Bloem B, Aasly J,Toft M, Pihlstrøm L, Correia Guedes L, J.Ferreira J, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, L. Pedersen N, Ran C, C. Belin A, Puschmann A, Ygland Rödström E, E. Clarke C, E.Morrison K, Tan M, Krainc D, F. Burbulla L, J. Farrer M, Krüger R, Gasser T, Sharma M, Vince N, Elbaz A.
On behalf of the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium, The Interaction between HLA-DRB1 and Smocking in Parkinson’s Disease Revisited, Mov Disord, 2022, 37(9), 1929-1937.

Domenighetti C, Sugier P-E, Ashok Kumar Sreelatha A, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili D-R, Radivojkov-Blagojevic M, Lichtner P, Singleton A-B, Hernandez D-G, Edsall C, Mellick G-D, Zimprich A, Pirker W, Rogaeva E, Lang A-E, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin M-C, Mutez E, Brockmann K, Deutschländer A-B, Hadjigeorgiou G-M, Dardiotis E, Stefanis L, Simitsi A-M, Valente E-M, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim Y-J, Kolber P, van de Warrenburg BPC, Bloem B-R, Aasly J, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira J-J, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen N-L, Ran C, Belin A-C, Puschmann A, Hellberg C, Clarke CE, Morrison K-E, Tan M, Krainc D, Burbulla L-F, Farrer M-J, Krüger R, Gasser T, Sharma M, Elbaz A and Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium.
Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study, Mov Disord, 2022, 37(4):857-864.

Domenighetti C, Sugier PE, Sreelatha AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin M-C, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BP, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A.
Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium, Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease, J Parkinsons Dis, 2022, 12(1), 267-282.

Ekmen A, Meneret A, Valabregue R, Beranger B, Worbe Y, Lamy JC, Mehdi S, Herve A, Adanyeguh I, Temiz G, Damier P, Gras D, Roubertie A, Piard J, Navarro V, Mutez E, Riant F, Welniarz Q, Vidailhet M, Lehericy S, Meunier S, Gallea C, Roze E.
Cerebellum Dysfunction in Patients With PRRT2-Related Paroxysmal Dyskinesia, Neurology, 2022, 98(10), e1077-e1089.

Fernández B, Chittoor-Vinod VG, Kluss JH, Kelly K, Bryant N, Nguyen APT, Bukhari SA, Smith N, Lara Ordóñez AJ, Fdez E, Chartier-Harlin M-C, Montine TJ, Wilson MA, Moore DJ, West AB, Cookson MR, Nichols RJ, Hilfiker S.
Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity, J Parkinsons Dis, 2022, 12(5), 1423-1447.

Grover S, Ashwin AKS, Pihlstrom L, Domenighetti C, Schulte C, Sugier P-E, Radivojkov-Blagojevic M, Lichtner P, Mohamed O, Portugal B, Landoulsi Z, May P, Bobbili D, Edsall C, Bartusch F, Hanussek M, Krüger J, Hernandez D-G, Blauwendraat C, Mellick G-D, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol J-C, Chartier-Harlin M-C, Mutez E, Brockmann K, Deutschländer A-B, Hadjigeorgiou G-M, Dardiotis E, Stefanis L, Simitsi A-M, Valente E-M, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Burbulla L-F, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung S-J, Kim Y-J, Pavelka L, van de Warrenburg B-P, Bloem B-R, Singleton A-B, Aasly J, Toft M, Guedes L-C, Ferreira J-J, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen N-L, Ran C, Belin A-C, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Krainc D, Farrer MJ, Kruger R, Elbaz A, Gasser T, Sharma M; and the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium.
Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson Disease: Evidence From COURAGE-PD Consortium, Neurology, 2022, 99(7), e698-e710.

Hernández S, Feracci M, De Jesus CT, El Kazzi P, Kaci R, Garlatti L, Mondielli C, Bailly F, Cotelle P, Touret F, de Lamballerie X, Coutard B, Decroly E, Canard B, Ferron F, Alvarez K.
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay, Antivir Res, 2022, 204, 105364.

Kozlova A, Thabault L, Dauguet N , Deskeuvre M , Stroobant V , Pilotte L , Liberelle M , Van den Eynde B, Frédérick R.
Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 23-dioxygenase, Eur J Med Chem, 2022, 227, 113892.

Kreisler A, Djelad S, Simonin C, Baille G, Mutez E, Degardin A, Defebvre L, Labreuche J, Cailliau E, Duhamel A.
Does ultrasound-guidance improve the outcome of botulinum toxin injections in cervical dystonia? Rev Neurol (Paris), 2022, 178(6), 591-602.

Liberelle M, Toulotte F, Renault N, Gelin M, Allemand F, Melnyk P, Guichou J-F, Cotelle P.
Towards the design of selective ligands of TEAD C-terminal domain, J Med Chem, 2022, 65, 5926-5940.

Liu H, Dehestani M, Blauwendraat C, Makarious M-B, Leonard H, Kim J-J, Schulte C, Noyce A, Jacobs B-M, Foote I, Sharma M, International Parkinson's Disease Genomics Consortium, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease Consortium, Nalls M, Singleton A, Gasser T, Bandres-Ciga S.
Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors, Ann Neurol, 2022, 92, 270-278.

Marc S, Mésangeau C, Coevoet M, Barczyk A, Burlet S, Verwaerde P, Brantis C, Sergeant N, Carato P, Melnyk P.
Pharmacomodulations around an anti-Alzheimer drug-candidate, Eur J Med Chem Rep, 2021, 4, 100020.

Marchand A, Sarchione A, Athanasopoulos P-S, Roy H-B, Goveas L, Magnez R, Drouyer M, Emanuele M, Ho F-Y, Liberelle M, Melnyk P, Lebègue N, Thuru X, Nichols R-J, Greggio E, Kortholt A, Galli T, Chartier-Harlin M-C, Taymans J-M.
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Marteau R, Ravez S, Mazhari D, Bouchaoui H, Porte K, Devedjian JC, Melnyk P, Devos D, Frederick R, El Bakali J.
Repositioning of FDA-Approved Antifungal Agents to interrogate Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) inhibitors in Ferroptosis, Biochem Pharmacol, 2022, 204, 115239.

Mésangeau C, Carato P, Renault N, Coevoet M, Barczyk A, Buée L, Sergeant N, Melnyk P.
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Oxombre B, Madouri F, Journé A-S, Ravez S, Woitrain E, Odou P, Duhal N, Ninni S, Montaigne D, Delhem N, Vermersch P, Melnyk P.
Safe and efficient sigma1 ligand: a potential drug candidate for Multiple Sclerosis, Int J Mol Sci, 2022, 23(19), 11893.

Quenon C, Hennebelle T, Butaud J-F, Ho R, Samaillie J, Neut C, Lehartel T, Rivière C, Siah A, Bonneau N, Sahpaz S, Anthérieu S, Lebègue N, Raharivelomanana P, Roumy V.
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Rona G, Zeke A, Miwatani-Minter B, de Vries M, Kaur R, Schinlever A, Garcia S.F, Goldberg H.V, Wang H, Hinds T.R, Bailly F, Zheng N, Cotelle P, Desmaële D, Landau N.R, Dittmann M, Pagano M.
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target, Cell Death Differ, 2022, 29, 285-292.

Sileo P, Simonin C, Melnyk P, Chartier-Harlin M-C, Cotelle P.
Crosstalk between Hippo pathway and Wnt pathway in Huntington’s disease and other neurodegenerative disorders, Cells, 2022, 11, 3631.

Thabault L, Brustenga C, Savoyen P, Van Gysel M, Wouters J, Sonveaux P, Frédérick R, Liberelle M.
Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade, Eur J Med Chem, 2022, 230, 114102.

Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL.
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design, Front Mol Biosci, 2022, 9, 880432.

Zagiel B, Melnyk P, Cotelle P.
Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present), Expert Opin Ther Pat, 2022, 32 (8), 899-912.

Zhao F, Abdellaoui M, Hagui W, Ballarin M, Berthet J, Corcé V, Delbaere S, Dossmann H, Espagne A, Forte J, Jullien L, Le Saux T, Mouriès-Mansuy V, Ollivier C, Fensterbank L.
Reactant-Induced Photoactivation of In Situ Generated Organogold Intermediates Leading to Alkynylated Indoles via Csp2-Csp Cross-Coupling, Nat Commun, 2022, 13, 2295.

Cresto N, Gardier C, Gaillard MC, Gubinelli F, Roost P, Molina D, Josephine C, Dufour N, Auregan G, Guillermier M, Bernier S, Jan C, Gipchtein P, Hantraye P, Chartier-Harlin M-C, Bonvento G, Van Camp N, Taymans J-M, Cambon K, Liot G, Bemelmans AP, Brouillet E.
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo, Int J Mol Sci, 2021, 22(13), 6760.

Drouyer M, Bolliger MF, Lobbestael E, Van den Haute C, Emanuele M, Lefebvre R, Sibran W, De Wit T, Leghay C, Mutez E, Dzamko N, Halliday GM, Murayama S, Martoriati A, Cailliau K, Bodart JF, Chartier-Harlin M-C, Baekelandt V, Nichols RJ, Taymans J-M.
Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation, Neurobiol Dis, 2021, 157, 105426.

Ettaoussi M, Laversin A, Vreulz B, Rami M, Lebègue N, Delagrange P, Caignard D-H, Melnyk P, Liberelle M, Yous S.
Synthesis and SAR studies of Novel Isoquinoline and Tetrahydroisoquinoline Derivatives as Melatonin Receptor Ligands, Chem Med Chem, 2021, 17(3), e202100658.

Fedorova OA, Arkhipova AN, Panchenko PA, Berthet J, Delbaere S, Minkovska S, Fedorov YV.
Fluorescent photochromic complex of 1,8-naphthalimide derivative and benzopyrane containing benzo-18-crown-6 ether, J Photochem Photobiol A-Chem, 2021, 405.

Gibault F, Bailly F, Sturbaut M, Coevoet M, Pugniez M, Magnez R, Thuru X, Melnyk P, Allemand F, Hong W, Pobbati A, Guichou JF, Cotelle P.
Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex, Chem Med Chem, 2021, 16 (18), 2823-2844.

Goveas L, Mutez E, Chartier-Harlin M-C, Taymans J-M.
Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells, Cells, 2021, 10(5), 981.

Graca V, Berthet J, Sousa CM, Delbaere S, Coelho PJ.
Synthesis of Vinylnaphthofurans and NMR Analysis of their Photoswitching, Eur J Org Chem, 2021, 13, 1979-1988.

Kozlova A, Thabault L, Liberelle M, Klaessens S, Prevost J, Mathieu C, Pilotte L, Stroobant V, Van den Eynde B, Frédérick R.
Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 23-Dioxygenase, J Med Chem, 2021, 64(15), 10967–10980.

Le Maréchal M, Mailles A, Seigneurin A, Tattevin P, Stahl JP, Épaulard O, Scientific Committee and Investigators Group.
A Prospective Cohort Study to Identify Clinical, Biological, and Imaging Features That Predict the Etiology of Acute Encephalitis, Clin Infect Dis, 2021, 73(2), 264-270.

Pacot L, Vidaud D, Sabbagh A, Laurendeau I, Briand-Suleau A, Coustier A, Maillard T, Barbance C, Morice-Picard F, Sigaudy S, Glazunova OO, Damaj L, Layet V, Quelin C, Gilbert-Dussardier B, Audic F, Dollfus H, Guerrot AM, Lespinasse J, Julia S, Vantyghem MC, Drouard M, Lackmy M, Leheup B, Alembik Y, Lemaire A, Nitschké P, Petit F, Dieux Coeslier A, Mutez E, Taieb A, Fradin M, Capri Y, Nasser H, Ruaud L, Dauriat B, Bourthoumieu S, Geneviève D, Audebert-Bellanger S, Nizon M, Stoeva R, Hickman G, Nicolas G, Mazereeuw-Hautier J, Jannic A, Ferkal S, Parfait B, Vidaud M, Members Of The Nf France Network, Wolkenstein P, Pasmant E.
Severe Phenotype in Patients with Large Deletions of NF1, Cancers (Basel), 2021, 13(12), 2963.

Sarchione A, Marchand A, Taymans J-M, Chartier-Harlin M-C.
Alpha-Synuclein and Lipids: The Elephant in the Room? Cells, 2021, 10(9), 2452.

Shabajee-Alibay P, Bonnaud A, Malpaux B, Delagrange P, Audinot V, Yous S, Boutin JA, Stephan J-P, Leprince J, Legros C.
A Putative new melatonin binding site in sheep brain, MTx: preliminary observations and characteristics, J Pharmacol Exp Therap, 2021, 380, 76–89.

Spillier Q, Ravez S, Dochain S, Vertommen D, Thabault L, Feron O, Frédérick R.
Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments, Molecules, 2021, 26(2), 477.

Stoup N, Liberelle M, Schulz C, Cavdarli S, Vasseur R, Magnez R, Lahdaoui F, Skrypek N, Peretti F, Frenois F, Thuru X, Melnyk P, Renault N, Jonckherre N, Lebègue N, Van Seuningen I.
The EGF domains of MUC4 oncomucin mediate HER2 binding affinity and promote pancreatic cancer cell tumorigenesis, Cancers, 2021, 13(22), 5746.

Sturbaut M, Bailly F, Coevoet M, Sileo P, Pugniere M, Liberelle M, Magnez R, Thuru X, Chartier-Harlin M-C, Melnyk P, Gelin M, Allemand F, Guichou JF, Cotelle P.
Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors, Eur J Med Chem, 2021, 226, 113835-849.

Tautou M, Eddarkaoui S, Descamps F, Larchanché PE, El Bakali J, Goveas L, Dumoulin M, Lamarre C, Blum D, Buée L, Melnyk P, Sergeant N.
A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration, Front Pharmacol, 2021, 12, 679335.

Taymans J-M.
Specialty Grand Challenge for Molecular Signalling and Pathways in Molecular Neuroscience, Front Mol Neurosci, 2021, 14, 694776.

Thabault L, Liberelle M, Frédérick R.
Targeting proteins self-association in drug design, Drug Discov Today, 2021, 26(5), 1148-63.

Thabault L, Liberelle M, Koruza K, Yildiz E, Joudiou N, Messens J, Brisson L, Wouters J, Sonveaux P, Frédérick R.
Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides, J Biol Chem, 2021, 296, 100422.

Bachoud-Lévi, AC on behalf the Multicentric Intracerebral Grafting in Huntington's Disease Group.
Human Fetal Cell Therapy in Huntington's Disease: A Randomized, Multicenter, Phase II Trial, Mov Disord, 2020, 35(8), 1323-1335.

Belarbi K, Cuvelier E, Bonte MA, Desplanque M, Gressier B, Devos D, Chartier-Harlin M-C.
Glycosphingolipids and neuroinflammation in Parkinson’s disease, Mol Neurodegener, 2020, 15,.

Desplanque M, Bonte MA, Gressier B, Devos D, Chartier-Harlin M-C, Belarbi K.
Trends in glucocerebrosides research: a systematic review, Front Physiology, 2020, 29,11, 558090.

El-Kashef H, Badr G, Abo El-Maali N, Sayed D, Melnyk P, Lebègue N, Abd El-Khalek R.
Synthesis of a novel series of (Z)-3,5-disubstituted thiazolidine-2,4-diones as promising anti-breats cancer agents, Bioorg Chem, 2020, 96,103569.

Hamdi I, Buntinx G, Aloïse S, Tiwari A K, Delbaere S, Takeshita M.
Cyclization Dynamics and competitive processes of photochromic perfluorocyclopentene dithienylethylene in solution, ChemPhysChem, 2020, 21, 2223-2229.

Hurtevent A, Le Naour M, Leclerc V, Carato P, Melnyk P, Hennuyer N, Staels B, Beucher-Gaudin M, Dacquet C, Lebègue N.
6-Benzoyl-benzothiazol-2-one as an important scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists, nzyme Inhib Med Chem, 2020, 35(1), 524-538.

Keo A, Mahfouz A, Ingrassia AMT, Meneboo JP, Villenet C, Mutez E, Comptdaer T, Lelieveldt BPF, Figeac M, Chartier-Harlin M-C, van de Berg WDJ, van Hilten JJ, Reinders MJT.
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Kreisler A, Simonin C, Degardin A, Mutez E, Defebvre L.
Anatomy-guided injections of botulinum neurotoxin in neck muscles: how accurate is needle placement? Eur J Neurol, 2020, 27(11), 2142-46.

Leguen C, Mazzah A, Penhoat M, Melnyk P, Rolando C, Chausset-Boissarie L.
Direct and regioselective fluorination of pyridylic and quinolinic C(sp3)-H bonds with selectfluor, Synthesis,, 2020, 53 (06), 1157-1162.

Liberelle M, Jonckheere N, Melnyk P, Van Seuningen I, Lebègue N.
EGF-containing membrane-bound Mucins : a hidden ErbB2 signaling pathway ? J Med Chem, 2020, 63(10), 5074-5088.

Lobbestael E, Van den Haute C, Macchi F, Taymans J-M, Baekelandt V.
Pathogenic LRRK2 requires secondary factors to induce cellular toxicity, Bioscience Rep, 2020, 40(10), BSR20202225.

Mangone G, Bekadar S, Cormier-Dequaire F, Tahiri K, Welaratne A, Czernecki V, Pineau F, Karachi C, Castrioto A, Durif F, Tranchant C, Devos D, Thobois S, Meissner WG, Navarro MS, Cornu P, Lesage S, Brice A, Welter ML, Corvol JC, contributors/investigators.
Early cognitive decline after bilateral subthalamic deep brain stimulation in Parkinson's disease patients with GBA mutations, Parkinsonism Relat Disord, 2020, 76, 56-62.

Marchand A, Drouyer M, Sarchione A, Chartier-Harlin M-C, Taymans J-M.
LRRK2 Phosphorylation, More Than an Epiphenomenon, Front Neurosci, 2020, 14, 527.

Norel L, Bernot K, Gendron F, Gould C, Roisnel T, Delbaere S, Le Guennic B, Jacquemin D, Rigaut S.
Coordination-enhanced photochromism in dysprosium dinuclear complexes with photomodulated single-molecule magnet behavior, Chem2, 2020, 4, 2.

Spillier Q, Ravez S, Unterlass J, Corbet C, Degavre C, Feron O, Frédérick R.
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Rascol O, Negre-Pages L, Damier P, Delval A, Derkinderen P, Destée A, Fabbri M, Meissmer WG, Rachdi A, Tison F, Perez-Lloret S for the COPARK study group.
Excessive buccal saliva in patients with Parkinson''s disease of the French COPARK cohort, J Neural Transm (Vienna), 2020, 127, 1607-1617.

Rascol O, Negre-Pages L, Damier P, Delval A, Derkinderen P, Destée A, Fabbri M, Meissmer WG, Rachdi A, Tison F, Perez-Lloret S for the COPARK study group.
Utilization Patterns of Amantadine in Parkinson''s Disease Patients Enrolled in the French COPARK Study, Drugs Aging, 2020, 37, 215-223.

Ribeiro JA, Hammer A, Libreros-Zúñiga GA, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise-Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB.
Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis, ACS Infect Dis, 2020, 6(8), 2192-2201.

Rideout HJ, Chartier-Harlin M-C, Fell MJ, Hirst WD, Huntwork-Rodriguez S, Leyns CEG, Mabrouk OS, Taymans J-M.
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease, Front Neurosci, 2020, 14, 865.

Thabault L, Brisson L, Brustenga C, Martinez Gache SA, Prévost J, Kozlova A, Spillier Q, Liberelle M, Benyahia Z, Messens J, Copetti T, Sonveaux P, Frédérick R.
Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides, J Med Chem, 2020, 63(9),4628-4643.

Aibidi Y, Guerrin C, Aleveque O, Leriche P, Delbaere S, Sanguinet L, Champagne B.
BT-2-BOX: an assembly toward multi-modal and multi-level molecular system simple as a breeze, J Phys Chem C, 2019, 123(18), 11823.

Berthet J, Agouridas L, Chen S, Allouchi H, Melnyk P, Champagne B, Delbaere S.
Synthesis and Photoswitching properties of new derivatives of azoresveratrol, Dyes Pigment, 2019, 171, 107666.

Blaise AS, Baille G, Carrière N, Devos D, Dujardin K, Grolez G, Kreisler A, Kyheng M, Moreau C, Mutez E, Seguy D, Lefebvre L.
Safety and effectiveness of levodopa-carbidopa intestinal gel for advanced Parkinson's disease: A large single-center study, Rev Neurol (Paris), 2020, 176 (4), 268-276.

Braisch U, Muche R, Rothenbacher D, Landwehrmeyer GB, Long JD, Orth M; REGISTRY Investigators of the European Huntington's Disease Network and COHORT Investigators of the Huntington Study Group.
Identification of symbol digit modality test score extremes in Huntington's disease, Am J Med Genet B Neuropsychiatr Genet, 2019, 180(3), 232-245.

Fernández B, Lara Ordóñez AJ, Fdez E, Mutez E, Comptdaer T, Leghay C, Kreisler A, Simonin C, Vandewynckel L, Defebvre L, Destée A, Bleuse S, Taymans J-M, Chartier-Harlin M-C, Hilfiker S.
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients, Biochemical J, 2019, 476(19), 2797-2813.

Graça VC, Calhelha RC, Nunes FM, Berthet J, Ferreira ICFR, Santos PF.
Isolation of secondary metabolites from Geranium molle L. with anticancer potential, Ind Crops Prod, 2019, 142, 1-5.

Guerrin C, Aibidi Y, Sanguinet L, Leriche P, Aloise S, Orio M, Delbaere S.
When light and acid play Tic-Tac-Toe with a nine-state molecular switch, J Am Chem Soc, 2019, 141(48), 19151.

Hamdi I, Buntinx G, Poizat O, Delbaere S, Perrier A, Rikiya Y, Ken-ichi M, Takeshita M, Aloïse S.
Unraveling Ultrafast Dynamics of the Photoswitchable Bridged Dithienylethenes Under Structural Constraints, Phys Chem Chem Phys, 2019, 21, 6407.

Issa S, Prandina A, Bedel N, Rongved P, Yous S, Le Borgne M, Bouaziz Z.
Carbazole scaffolds in cancer therapy: a review from 2012 to 2018, J Enzyme Inhib Med Chem, 2019, 34(1), 1321-1346.

Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V.
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity, Nature, 2019, 569(7755), 289-292.

Liberelle M, Magnez R, Thuru X, Bencheikh Y, Ravez S, Quenon C, Drucbert AS, Foulon C, Melnyk P, Van Seuningen I, Lebègue N.
MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis and Surface Plasmon Resonance, Sci Rep, 2019, 9, 16678-85.

Makrane H, Aziz M, Berrabah M, Mekhfi H, Ziyyat A, Bnouham M, Legssyer A, Elombo FK, Gressier B, Eto B.
Myorelaxant Activity of essential oil from Origanum majorana L. on rat and rabbit, J Ethnopharmacol, 2019, 228, 40-49.

Makrane H, Aziz M, Mekhfi H, Ziyyat A, Legssyer A, Melhaoui A, Berrabah M, Bnouham M, Alem C, Elombo FK, Gressier B, Desjeux JF, Eto B.
Origanum majorana L extract exhibit positive cooperative effects on the main mechanisms involved in acute infectious diarrhea, J Ethnopharmacol, 2019, 239, 111503.

Mrabti HN, El Abbes Faouzi M, Mayuk FM, Makrane H, Limas-Nzouzi N, Dibong SD, Cherrah Y, Elombo FK, Gressier B, Desjeux JF, Eto B.
Arbutus unedo L., (Ericaceae) inhibits intestinal glucose absorption and improves glucose tolerance in rodents, J Ethnopharmacol, 2019, 235, 385-391.

Rami M, Winum JY, Supuran C, Melnyk P, Yous S.
(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators, J Enzyme Inhib Med Chem, 2019, 34 (1), 224-229.

Reilmann R McGarry A, Grachev ID, Savola JM, Borowsky B, Eyal E, Gross N, Langbehn D, Schubert, R, Wickenberg AT, European Huntingtons Dis Network, Huntington Study Grp Inv.
Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study, Lancet Neurol, 2019, 18(2), 165-176.

Saez-Ayala M, Laban Yekwa E, Mondielli C, Roux L, Hernández S, Bailly F, Cotelle P, Rogolino D, Canard B, Ferron F, Alvarez K.
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain, Antivir Res, 2019, 162, 79-89.

Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Lefur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P.
New piperazine multi-action drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer’s disease, Neurobiol Dis, 2019, S0969-9961, 30327-9.

Sousa CM, Berthet J, Delbaere S, Coelho PJ.
Enhancement of the color intensity of photochromic fused-naphthopyrans, Dyes Pigment 2019, 1, 9, 118-124.

Spillier Q, Vertommen D, Ravez S, Marteau R, Thémans Q, Corbet C, Feron O, Wouters J, Frédérick R.
Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation, Sci Rep, 2019, 9(1), 4737.

Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V.
Structural basis of ligand recognition at the human MT1 melatonin receptor, Nature, 2019, 569(7755), 284-288.

Blauwendraat C, Reed X, Kia DA, Gan-Or Z, Lesage S, Pihlstrøm L, Guerreiro R, Raphael Gibbs J, Sabir M, Ahmed S, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Hernandez DG, Chung SJ, Goldwurm S, Toft M, Schulte C, Bras J, Wood NW, Brice A, Morris HR, Scholz SW, Mike A Nalls MA, Singleton AB, Cookson MR, COURAGE-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease) Consortium, the French Parkinson’s Disease Consortium, and the International Parkinson’s Disease Genomics Consortium (IPDGC).
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease, JAMA Neurol, 2018, 75, 1416-1422.

Erik Boot, MD, PhD, Nancy J. Butcher, PhD, Sean Udow, MD, FRCP(C), Connie Marras, MD, PhD, Kin Y. Mok, FRCP, Satoshi Kaneko, MD, PhD, Matthew J. Barrett, MD, MSc, Paolo Prontera, MD, PhD, Brian D. Berman, MD, MS, Mario Masellis, MD, PhD, Boris Dufournet, MD, Karine Nguyen, MD, Perrine Charles, MD, Eugénie Mutez, MD, PhD, Teodor Danaila, MD, PhD, Aurélia Jacquette, MD, Olivier Colin, MD, Sophie Drapier, MD, Michel Borg, MD, Ania M. Fiksinski, MSc, Elfi Vergaelen, MD, Ann Swillen, PhD, Annick Vogels, MD, PhD, Annika Plate, MD, Claudia Perandones, MD, PhD, Thomas Gasser, MD, Kristien Clerinx, MD, Frédéric Bourdain, MD, Kelly Mills, MD, MHS, Nigel M. Williams, PhD, Nicholas W. Wood, PhD, FRCP, FmedSci, Jan Booij, MD, PhD, Anthony E. Lang, MD, MRCPC, and Anne S. Bassett, MD, FRCPC On behalf of the International Research Group.
Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2, Neurology, 2018,.

Boulahjar R, Rincon Arias A, Bolteau R, Renault N, Coevoet M, Barczyk A, Duroux R, Yous S, Melnyk P, Agouridas L.
Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure, Bioorg Med Chem, 2018, 26, 3296-3307.

Cormier-Dequaire F, Bekadar S , Anheim M, Lebbah S, Pelissolo A, Krack P, Lacomblez L, Lhommée E, Castrioto A, Azulay JP, Defebvre L, Kreisler A, Durif F, Marques-Raquel A, Brefel-Courbon C, Grabli D, Roze E, Llorca PM, Ory-Magne F, Benatru I, Ansquer S, Maltête D, Tir M, Krystkowiak P, Tranchant C, Lagha-Boukbiza O, Lebrun-Vignes B, Mangone G, Vidailhet M, Charbonnier-Beaupel F, Rascol O, Lesage S, Brice A, Tezenas du Montcel S, Corvol JC, BADGE-PD study group.
Suggestive association between OPRM1 and impulse control disorders in Parkinson’s disease, Mov Disord, 2018, 33(12), 1878-1886.

Cuvelier E, Méquinion M, Leghay C, Sibran W, Stievenard A, Sarchione A, Bonte MA, Vanbesien-Mailliot C, Viltart O, Saitoski K, Caron E, Labarthe A, Comptdaer T, Semaille P, Carrié H, Mutez E, Gressier B, Destée A, Chartier-Harlin MC, Belarbi K.
Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice, Front Mol Neurosci, 2018, 11, 321.

Duroux R, Agouridas L, Renault N, El Bakali J, Furman C, Melnyk P, Yous S.
Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity, Eur J Med Chem, 2018, 144, 151-63.

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