Leila Moum

Structural resolution and therapeutic targeting of the oncogenic MUC4-Her2 complex for the treatment of pancreatic cancer

Director: Nicolas Lebègue

Juliette Lafon

Development of inhibitors of long-chain acyl-CoA synthetase 4 (ACSL4) for therapeutic purposes

Director: Jamal El Bakali

Lisa Brisoire

Understanding the mode of action of small anti-Alzheimer molecules on amyloid precursor protein metabolism and Aβ peptide production

Director: Nicolas Sergeant

Marie Stoup

Elucidation of structure-function relationships and therapeutic targeting of LRRK2-phosphatase complexes in Parkinson's disease

Directors: Said Yous / Maxime Liberelle

Alessio Burin

Targeting the molecular pathway of LRRK2, a signaling protein in Parkinson's disease

Director: Jean-Marc Taymans

Maureen Fina

Contribution of bio-orthogonal chemistry to the functionalization of a pharmacophore, the study of compound/biological target complexes and the characterization of the target of "anti-Alzheimer"compounds

Director: Patricia Melnyk

Clémence Delassus

Understanding the mode of action of an anti-Alzheimer drug candidate

Director: Nicolas Sergeant

Ilona Ryckewart

Development of new ACSL4 inhibitors to block ferroptosis in Parkinson's disease

Director : Jamal El Bakali

Quentin Broyant

Study of LRRK2 : GAK and LRRK2 : auxilin complexes in endocytosis associated with Parkinson's disease

Directeur : Jean Marc Taymans

Romain Moore

Design, synthesis and evaluation of ligands of interface 2 of the transcription factor TEAD, modulators of the Hippo pathway

Director : Nicolas Lebègue