Scientific summary

• Discovery of new functions of tau protein: Beyond its known role in stabilizing microtubules, the team identified new functions of tau protein, including interaction with DNA, RNA, and regulation of cellular metabolism, particularly glucose. These new functions could explain how abnormalities in tau protein contribute to the development of tauopathies.
• Spread of tau protein in the brain: The researchers studied the mechanisms of spread of tau protein from one cell to another, a key process in the development of tauopathies. They showed that tau protein can spread in a similar way to an infectious agent, by inducing the conversion of other tau proteins into a pathological form.
• Link between tauopathies and metabolism: The team established a link between tauopathies and metabolism, particularly glucose metabolism. They showed that abnormalities in the tau protein can disrupt glucose metabolism in the brain and other organs, such as the pancreas.
• Development of animal models: Researchers have developed animal models of tauopathies to study the molecular mechanisms of these diseases and test new therapies. These models have provided insight into the role of the tau protein in the development of neurodegenerative diseases.

Implications for research

The results of this research open new perspectives for the development of treatments for tauopathies. By identifying new therapeutic targets, such as the non-canonical functions of the tau protein and the mechanisms of disease propagation, the researchers hope to be able to develop more effective treatments to slow or stop the progression of these devastating diseases.

In summary, the team has made fundamental contributions to the understanding of the molecular mechanisms involved in tauopathies. These discoveries open new avenues for the development of treatments and offer hope for patients suffering from these neurodegenerative diseases.