Go to content
Université de Lille
Laboratoire Centre de Recherche Lille Neuroscience & Cognition | Lille Neuroscience & Cognition Lille Neuroscience & Cognition
U 1172
  • Contact
  • X ( New window)
    • FR
  • Contact
  • X ( New window)
    • FR
  • The Center
    • Our Lab
    • Organizational chart
    • Techniques and equipment
    • Contact
    • Access
  • Research Teams
    • TREAT
      • Research axes
      • Research Projects
      • Our Spin-off
        • InBrain Pharma
        • InVenis Biotherapies
      • Partner Institutions & Financial Support
      • Portfolio
        • Item 1 - Translational research design
        • Item 2 - Virtual biopsy in neurodegenerative diseases
        • Item 3
        • Item 4 - Axial symptoms as a biomarker of neurodegenerative diseases: multimodal approach and usefulness of connected devices
        • Item 5 - Transforming the prognosis of intracerebral hemorrhage
        • Item 6 - Iron dyshomeostasis, ferroptosis, a new type of iron-related regulated cell death
        • Item 7 - New therapeutic strategies thanks to pharmacological cerebral modulation
      • Members
        • Researchers-Associate Professors
        • Research Support Staff
        • CDD Researchers
        • Doctoral Students
        • Alumni
      • News
        • Videos & podcasts
        • Press
        • Scientific awards and distinctions
      • Publications
        • 2024
        • 2023
        • 2022
        • 2021
        • 2020
    • TREND
      • Our Lab
      • Research themes
        • Summary for the general public
        • Scientific summary
        • Extrinsic mechanisms of the Tau protein and its pathology
        • Our other areas of Research
      • Publications
        • 2024
        • 2023
        • 2022
        • 2021
        • 2020
        • 2019
      • Members
        • Researchers
        • Teacher Researchers
        • Hospital-University Researchers
        • Research support staff
        • Contract researchers
        • Doctoral students
        • Alumni
      • News
        • Videos
        • In the Press
    • BEƎꟼ
      • A dedicated platform
      • Research programs
        • Within-subject mental representations
        • Between-subjects mental representations
        • Computational Psychiatry
      • Members
      • News
      • I contribute
      • Publications
    • IT4BD
      • Research Topics
        • LRRK2 & Parkinson's Disease
        • ACSL4 & Ferroptosis
        • Proteostasis modulators and Alzheimer’s Disease
        • TEAD modulators
      • Members
        • Professors & associate professors
        • Researchers
        • University Hospital Researchers
        • Support staff
        • Contract researchers
        • Doctoral students
        • Alumni
      • Publications
      • News
    • Lille Neuroendocrinology
      • Our lab
      • Research Interests and expertise
        • Structuring projects
        • Research topics
        • Memberships and funding
        • Platforms and techniques
      • Members
        • Principal Investigators
        • European Project Coordinator
        • Clinical partners
        • Technical Staff
        • Post-Doctoral Fellows
        • Doctoral students
        • Alumni
      • Publications/Seminars
        • Publications
        • Conferences & Symposia
        • Invited Seminars
      • News
        • Awards
        • Videos and Podcasts
        • In the media
        • Social networks
    • Interactions
      • Research environment
      • Works
        • Our projects
        • 2018-2023 Report
      • Members
        • Permanent Researchers
        • Postdoctoral Researchers
        • PhD students
        • Research Support Staff
        • Clinicians
      • Collaborations
      • Publications
        • Publications 2024
        • Publications 2025
      • Media and Events
  • Job offers
    • Thesis offer
    • Internship offer
    • Technical contract offer
    • Researcher contract offer
  • Science for all
    • What diseases ?
    • MT180
    • "Déclics"
    • "Apprentice researchers"
    • The Brain week
    • World Alzheimer’s Day
    • The Memory Week
    • "Science Festival"
  • Lab life
    • Doctoral students Journal
    • Newsletter
  • Calendar
    • Archives
  • News
  • Publications
  1. LilEnCog
  2. >
  3. Research Teams
  4. >
  5. BEƎꟼ
  6. >
  7. Research programs
  8. >
  9. Computational Psychiatry
BEƎꟼ
  • A dedicated platform
  • Research programs
    • Within-subject mental representations
    • Between-subjects mental representations
    • Computational Psychiatry
  • Members
  • News
  • I contribute
  • Publications

Computational Psychiatry

Modelling neuropsychiatric disorders

This line of research focuses on modeling mathematically the multiscale mechanisms underlying perception and decision-making under uncertainty. We refer to several clinical contexts from the field of psychiatry, with a special emphasis on psychotic disorders. We combine data from experimental psychology, psychophysics, fMRI, pharmacogenetic modulation, multi-electrode signaling in humans and/or rodents.

Contacts

  • Pierre Yger
  • Pantélis Leptourgos
  • Renaud Jardri

Key publications

  • Neurosci Biobehav Rev, 2022 

The Circular Inference model

Our brain is constantly trying to resolve the uncertainty of the surrounding world. To do this, it makes predictions about the possible causes of the signals it receives. These inference operations require the propagation of messages through the cortical hierarchy. The circular inference model introduced by Jardri and Denève (2013), proposes that these aberrant predictions are due to an amplification of circulating messages. This model has received behavioral validation in schizophrenia (Jardri et al., 2017) and our work now aims to reinforce its neurophysiological plausibility.

Ongoing research projects

Role of Excitation / Inhibition balance

We have seen that perception and cognition can be described in terms of Bayesian inference. From this point of view, the central nervous system, through learning and experience, captures statistics from the external world to update its internal probabilistic models and guide our behavior and actions. This research program aims to better understand how information is dynamically weighted by the brain during a decision-making task. Based on the circular inference model and a translational approach using similar tasks in rodents and humans, we are investigating the role played by the neuronal excitatory/inhibitory balance in the processing and integration of sensory information in physiological and/or pathological situations.

 

Spike sorting pipelines

In recent years, advances in multi-electrode arrays and high-density silicon electrodes have made it possible to record extracellular signals from hundreds of electrodes. These recordings offer the possibility of reconstructing the individual activity of neurons in the vicinity of each electrode using sophisticated signal processing algorithms. However, this reconstruction remains an open problem of blind source separation (BSS), also known as “spike sorting”, which is difficult to solve due to the constraints imposed by these new devices. Firstly, the number of dimensions (i.e. electrodes) is high: algorithms have to cope with the amount of extracellular data, entering a new era of Big Data (over hundreds of Gigabytes per recording). Secondly, the density of the electrodes and the high number of sources give rise to numerous source mixtures. Most strikingly, not all existing solutions today have the capacity to operate in an online context, which is essential for advanced brain-machine interfaces (BMIs). In the team, we are actively developping new algorithms to enhance the quality of spike-sorting pipelines used worldwide both for in-vitro and in-vivo recordings.

Centre de Recherche Lille Neuroscience & Cognition | Lille Neuroscience & Cognition
Lille Neuroscience & Cognition
  • X ( New window)
  • Accessibility : non-compliant
  • Legal Notice | Contact
  • Sitemap
Université de Lille ©  2025
Page updated on 04-25-2025 (10:48)
Université de Lille
INSERM
CHR Lille